Critical Role for Lysines 21 and 22 in Signal-induced, Ubiquitin-mediated Proteolysis of IkB-α
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چکیده
منابع مشابه
Ubiquitin-mediated proteolysis in plant hormone signal transduction.
Being sessile organisms, plants usually have little control over their immediate growth environment. Responses to environmental and developmental factors need to be rapid and finely coordinated to trigger the necessary morphological and metabolic changes that ensure plant survival and growth. Many of these adaptive responses are mediated by plant hormones. Recent work has shown that ubiquitin-m...
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15 صفحه اولCellular Contractility Requires Ubiquitin Mediated Proteolysis
BACKGROUND Cellular contractility, essential for cell movement and proliferation, is regulated by microtubules, RhoA and actomyosin. The RhoA dependent kinase ROCK ensures the phosphorylation of the regulatory Myosin II Light Chain (MLC) Ser19, thereby activating actomyosin contractions. Microtubules are upstream inhibitors of contractility and their depolymerization or depletion cause cells to...
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Mammalian telomeres are coated by the sequence-specific, DNA-binding protein, TRF1, a negative regulator of telomere length. Previous results showed that ADP-ribosylation of TRF1 by tankyrase 1 released TRF1 from telomeres and promoted telomere elongation. We now show that loss of TRF1 from telomeres results in ubiquitination and degradation of TRF1 by the proteasome and that degradation is req...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1996
ISSN: 0021-9258
DOI: 10.1074/jbc.271.1.376